Rocklage S M, Worah D, Kim S H
Salutar, Inc., Sunnyvale, California 94086.
Magn Reson Med. 1991 Dec;22(2):216-21; discussion 229-32. doi: 10.1002/mrm.1910220211.
At the currently administered clinical doses, paramagnetic metal chelate complexes presently used as MR contrast enhancement agents appear to be relatively nontoxic. Solution thermodynamic, solubility, and selectivity studies, based on a number of gadolinium chelate complexes, indicate that very little gadolinium is released in vivo, and the small amounts that do remain are available for excretion, albeit slowly. Although the mechanism of metal release from manganese-based chelate complexes is not well understood, any released manganese is likely to be quickly and efficiently cleared through the liver. Although MRI contrast agents are unlikely to be administered repeatedly in patients, which could result in accumulation of metal ion, the long-term effects of such potential deposition have yet to be demonstrated.
在当前使用的临床剂量下，目前用作磁共振成像（MR）造影增强剂的顺磁性金属螯合物复合物似乎相对无毒。基于多种钆螯合物复合物的溶液热力学、溶解度和选择性研究表明，体内释放的钆极少，而残留的少量钆虽可排出，但速度较慢。尽管基于锰的螯合物复合物释放金属的机制尚不完全清楚，但任何释放出的锰很可能会迅速且有效地通过肝脏清除。尽管磁共振成像造影剂不太可能在患者体内重复给药从而导致金属离子积累，但其潜在沉积的长期影响仍有待证实。
