Kwong K K, Xiong J, Kuan W P, Cheng H M
Howe Laboratory of Ophthalmology, Massachusetts General Hospital-NMR Center, Charlestown 02129.
Magn Reson Med. 1991 Dec;22(2):443-50. doi: 10.1002/mrm.1910220252.
Topically applied (eyedrop) H2(17)O (10% enrichment) was used in magnetic resonance studies to quantify intraocular water dispersion in vivo. The rate of H2(17)O removed from the aqueous chamber is in the order of 0.1 ml/min/ml of tissue. Similar results are obtained with either proton imaging or 17O spectroscopy. Parallel experiments of direct injection of H2(17)O into the aqueous chamber supported the topical data. Proton MR imaging of H2(17)O dissipation from the aqueous chamber with clinical imagers, coupled with eyedrop application, suggests clinical possibilities.
局部应用（滴眼剂）的H₂¹⁷O（富集度10%）被用于磁共振研究，以在体内定量眼内水分扩散。从房水腔中去除H₂¹⁷O的速率约为0.1毫升/分钟/毫升组织。质子成像或¹⁷O光谱学均可得到类似结果。将H₂¹⁷O直接注入房水腔的平行实验支持了局部应用的数据。利用临床成像仪对房水腔中H₂¹⁷O消散进行质子磁共振成像，并结合滴眼剂应用，显示了临床应用的可能性。
