Department of Molecular Imaging and Theranostics, National Institutes for Quantum Science and Technology.
Department of Radiology, Kanagawa Children's Medical Center.
Magn Reson Med Sci. 2022 Mar 1;21(1):235-252. doi: 10.2463/mrms.rev.2021-0085. Epub 2022 Feb 15.
MR spectroscopy (MRS) is a unique and useful method for noninvasively evaluating biochemical metabolism in human organs and tissues, but its clinical dissemination has been slow and often limited to specialized institutions or hospitals with experts in MRS technology. The number of 3-T clinical MR scanners is now increasing, representing a major opportunity to promote the use of clinical MRS. In this review, we summarize the theoretical background and basic knowledge required to understand the results obtained with MRS and introduce the general consensus on the clinical utility of proton MRS in routine clinical practice. In addition, we present updates to the consensus guidelines on proton MRS published by the members of a working committee of the Japan Society of Magnetic Resonance in Medicine in 2013. Recent research into multinuclear MRS equipped in clinical MR scanners is explained with an eye toward future development. This article seeks to provide an overview of the current status of clinical MRS and to promote the understanding of when it can be useful. In the coming years, MRS-mediated biochemical evaluation is expected to become available for even routine clinical practice.
磁共振波谱（MRS）是一种独特且有用的方法，可用于非侵入性地评估人体器官和组织中的生化代谢，但它的临床应用一直较为缓慢，通常仅限于具有 MRS 技术专家的专业机构或医院。现在，3-T 临床磁共振扫描仪的数量正在增加，这为推广临床 MRS 的应用提供了重要机会。在这篇综述中，我们总结了理解 MRS 结果所需的理论背景和基本知识，并介绍了质子 MRS 在常规临床实践中的临床应用的普遍共识。此外，我们还介绍了 2013 年日本磁共振医学学会工作组的成员发布的质子 MRS 共识指南的更新内容。本文还介绍了临床磁共振扫描仪配备的多核 MRS 的最新研究进展，着眼于未来的发展。本文旨在概述当前临床 MRS 的现状，并促进人们对其何时有用的理解。在未来几年，MRS 介导的生化评估有望在常规临床实践中得到应用。
