Jollès P
Experientia. 1976 Jun 15;32(6):677-83. doi: 10.1007/BF01919830.
The role of whole Mycobacteria, mycobacterial cell walls and waxes D as immunostimulants was well established many years ago. More recently three different research groups have shown that hydrosoluble components from mycobacterial and other bacterial origins were as active as waxes D or cell walls and were free of many side-effects. Studies concerning the relationship between structure and activity were achieved which led to the description of a small biologically active fragment and to a first series of synthetic compounds.
多年前就已充分确立了完整分枝杆菌、分枝杆菌细胞壁和蜡质D作为免疫刺激剂的作用。最近，三个不同的研究小组表明，来自分枝杆菌和其他细菌来源的水溶性成分与蜡质D或细胞壁具有相同的活性，并且没有许多副作用。开展了关于结构与活性之间关系的研究，这导致了一个小的生物活性片段的描述以及第一系列合成化合物的出现。
