一种来自分枝杆菌细胞壁的无毒水溶性免疫佐剂的生物学研究。
Biological study of a nontoxic, water-soluble immunoadjuvant from mycobacterial cell walls.
作者信息
Chedid L, Parant M, Parant F, Gustafson R H, Berger F M
出版信息
Proc Natl Acad Sci U S A. 1972 Apr;69(4):855-8. doi: 10.1073/pnas.69.4.855.
Abstract
Whole mycobacterial cells, which are used in Freund's complete adjuvant, besides inducing hypersensitivity to tuberculoprotein, also can elicit hyperreactivity to endotoxins, lymphoid hyperplasia, and allergic polyarthritis in rats. The data reported here demonstrate that a potent water-soluble adjuvant obtained from mycobacterial cell walls is also effective in increasing the immune response to viruses, and that it is free of the toxic effects observed with whole mycobacterial cells.
摘要
用于弗氏完全佐剂中的完整分枝杆菌细胞，除了能诱导对结核蛋白的超敏反应外，还会引发大鼠对内毒素的高反应性、淋巴组织增生和过敏性多关节炎。本文报道的数据表明，从分枝杆菌细胞壁获得的一种有效的水溶性佐剂在增强对病毒的免疫反应方面同样有效，并且没有观察到完整分枝杆菌细胞所具有的毒性作用。
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