Diacono J, Dietrich J
Farmaco Sci. 1976 Apr;31(4):277-83.
The effects of taurine on electrical properties of isolated myocardial ventricular fibres were studied in rat and guinea pig. The action potential amplitude was decreased in these species while the plateau and the repolarization phase were not altered. This suggests that simple inspection of the plateau phase is not sensitive enough to pick up changes in outward current since voltage clamp experiments showed that taurine decreased both potassium current and fast inward current. However, the slow inward calcium current remained unchanged with taurine in each species. These results suggest that the inotropic effects of taurine on rat and guinea pig heart contraction already described, were not due to modifications of the cell membrane permeability for calcium. It seems more reasonable to assume that the cardiac actions of this compound result from intracellular changes in calcium availability.
在大鼠和豚鼠中研究了牛磺酸对离体心肌心室纤维电特性的影响。在这些物种中，动作电位幅度降低，而平台期和复极化阶段未改变。这表明，由于电压钳实验表明牛磺酸降低了钾电流和快速内向电流，因此简单检查平台期对检测外向电流变化的敏感性不够。然而，在每个物种中，牛磺酸处理后慢内向钙电流保持不变。这些结果表明，先前描述的牛磺酸对大鼠和豚鼠心脏收缩的变力作用，并非由于细胞膜对钙的通透性改变所致。更合理的假设是，该化合物的心脏作用是由细胞内钙可用性的变化引起的。
