Cui Y, Tan Y H
Department of Pharmacology, 4th Military Medical University, Xi-an, China.
Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):311-4.
The effects of 3,6-dimethamidodibenzopyriodonium citrate (I-65) on action potentials and slow inward calcium current (I(si)) were examined on isolated guinea pig ventricular myocardial cells. I-65 (30-100 mumol.L-1) depressed the action potential duration at 20% repolarization (APD20) and, under voltage-clamp conditions, reduced the amplitude of I(si) without changing the I-V relations. I-65 also showed use-dependent effects on I(si). These suggest that I-65 may block I(si) by acting on the inactivated state of Ca channels.
在分离的豚鼠心室肌细胞上研究了3,6 - 二甲基氨基二苯并吡啶柠檬酸铵（I - 65）对动作电位和慢内向钙电流（I(si)）的影响。I - 65（30 - 100 μmol·L-1）使复极化20%时的动作电位时程（APD20）缩短，并且在电压钳条件下，降低了I(si)的幅度，而不改变I-V关系。I - 65对I(si)也表现出使用依赖性效应。这些表明I - 65可能通过作用于钙通道的失活状态来阻断I(si)。
