Richardson M D, Gray C A, Shankland G S
Department of Dermatology, University of Glasgow, U.K.
FEMS Microbiol Immunol. 1991 Nov;3(6):341-4. doi: 10.1111/j.1574-6968.1991.tb04259.x.
In the presence of autologous complement, maximal phagocytosis of Candida albicans blastospores of both a virulent and attenuated strain by human neutrophils in a monolayer assay was achieved after 30 min. The proportion of phagocytes containing intracellular blastospores was 33-36% with an average of 1.5 blastospores per phagocyte. In contrast to the attenuated strain of C. albicans, the virulent strain resisted opsonization by C-reactive protein (CRP) and of those blastospores ingested, only 8% were killed. These findings support the concept that CRP may play a protective role in candidosis independent of complement. The fate of strains of different virulence may be a result of differences in CRP receptors or killing mechanisms.
在存在自体补体的情况下，在单层试验中，人中性粒细胞对白色念珠菌的芽生孢子（包括强毒株和减毒株）的最大吞噬作用在30分钟后实现。含有细胞内芽生孢子的吞噬细胞比例为33%-36%，每个吞噬细胞平均含有1.5个芽生孢子。与白色念珠菌减毒株相比，强毒株抵抗C反应蛋白（CRP）的调理作用，在摄取的那些芽生孢子中，只有8%被杀死。这些发现支持了CRP可能在念珠菌病中独立于补体发挥保护作用的概念。不同毒力菌株的命运可能是CRP受体或杀伤机制差异的结果。
