Hunziker W, Mellman I
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Semin Cell Biol. 1991 Dec;2(6):397-410.
Epithelial cells use both the exocytic and endocytic pathways to generate and maintain the polarized distribution of membrane proteins. This review summarizes current information concerning the general features and functions of the exocytic and endocytic pathways in MDCK cells. We analyse the possible implications of similarities between signals for endocytosis and determinants for basolateral sorting in the TGN. Furthermore, we discuss the fundamental relationships that might also exist in the biochemical basis of membrane traffic in the two pathways.
上皮细胞利用胞吐和胞吞途径来产生并维持膜蛋白的极性分布。本综述总结了有关MDCK细胞中胞吐和胞吞途径的一般特征及功能的当前信息。我们分析了内吞信号与反式高尔基体网络（TGN）中基底外侧分选决定因素之间相似性的可能影响。此外，我们还讨论了这两种途径中膜运输生化基础可能存在的基本关系。
