Copinschi G, Leclercq-Meyer V, Virasoro E, L'Hermite M, Vanhaelst L, Golstein J, Leclercq R, Féry F, Robyn C
Horm Metab Res. 1976 May;8(3):226-31. doi: 10.1055/s-0028-1093646.
The effects of synthetic linear somatostatin on basal circulating levels on several pituitary and pancreatic hormones, and of glucose and free fatty acids (FFA) were studied in 6 normal men after an overnight fast. A priming intravenous infusion of 250 mug of somatostatin in 18 sec was followed by a constant infusion of 500 mug over a period of 60 min. A decrease in plasma values of GH, prolactin, TSH, insulin and glucagon and in blood glucose was observed during somatostatin infusion, while FFA levels increased progressively. Plasma IRI and blood glucose increased rapidly when the somatostatin infusion was stopped, while FFA decreased progressively; GH, prolactin, TSH and glucagon remained low as compared to basal levels for one hour after the end of the infusion, i.e. until the end of the experiment. A slight but significant increase of LH and ACTH was observed after the end of the infusion.
在6名过夜禁食的正常男性中，研究了合成线性生长抑素对几种垂体和胰腺激素基础循环水平以及葡萄糖和游离脂肪酸（FFA）的影响。先在18秒内静脉注射250微克生长抑素进行预充，随后在60分钟内持续输注500微克。在输注生长抑素期间，观察到生长激素（GH）、催乳素、促甲状腺激素（TSH）、胰岛素和胰高血糖素的血浆值以及血糖降低，而FFA水平逐渐升高。停止输注生长抑素后，血浆胰岛素瘤相关肽（IRI）和血糖迅速升高，而FFA逐渐降低；输注结束后一小时内，与基础水平相比，GH、催乳素、TSH和胰高血糖素仍保持在较低水平，即直到实验结束。输注结束后，观察到促黄体生成素（LH）和促肾上腺皮质激素（ACTH）有轻微但显著的升高。
