胰岛中促甲状腺激素释放激素的高浓度。
High concentration of thyrotropin-releasing hormone in pancreatic islets.
作者信息
Martino E, Lernmark A, Seo H, Steiner D F, Refetoff S
出版信息
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4265-7. doi: 10.1073/pnas.75.9.4265.
Abstract
The concentration of thyrotropin-releasing hormone (TRH, thyroliberin) in rat islets of Langerhans is 30-fold higher than in whole rat pancreas, indicating that the islets are the main source of pancreatic TRH. The TRH extracted from islets is indistinguishable from synthetic TRH in its immunological and biological properties and in its inactivation by human serum. The physiologic function of islet TRH is unknown. However, because TRH is antagonistic to somatostatin in other systems, and somatostatin also is concentrated in islets in high concentrations, it is possible that islet TRH may serve a similar antagonistic function in the regulation of islet cell secretory activity.
摘要
大鼠胰岛中促甲状腺激素释放激素（TRH，促甲状腺素释放素）的浓度比整个大鼠胰腺中的浓度高30倍，这表明胰岛是胰腺TRH的主要来源。从胰岛中提取的TRH在免疫和生物学特性以及被人血清灭活方面与合成TRH没有区别。胰岛TRH的生理功能尚不清楚。然而，由于TRH在其他系统中与生长抑素具有拮抗作用，且生长抑素在胰岛中也高度浓缩，因此胰岛TRH在调节胰岛细胞分泌活性方面可能具有类似的拮抗功能。
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Thyrotropin-releasing hormone stimulation and somatostatin inhibition of growth hormone secretion from perfused rat adenohypophyses.促甲状腺激素释放激素对灌注大鼠腺垂体生长激素分泌的刺激作用以及生长抑素对其的抑制作用。
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Effects of somatostatin on the secretion of thyrotropin and prolactin.生长抑素对促甲状腺激素和催乳素分泌的影响。
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