Wang Z
Institute of Orthopedics and Traumatology, Xijing Hospital, Fourth Military Medical University, Xian.
Zhonghua Wai Ke Za Zhi. 1991 Aug;29(8):489-91, 525.
The author employed the radioimmunoimaging technique in localizing osteosarcoma with the use of bone morphogenetic protein monoclonal antibodies (BMP-McAb). BMP-McAb which had been labelled with 125I or 131I by the chloramine T method was given in injection to patients, and imaging was performed on SPECT (single photon emission computed tomography) 24 or 48 hrs after the injection of antibodies. There were seven patients with osteosarcoma and one with parosteal osteosarcoma. The result of SPECT imaging confirmed of the tumor areas of osteosarcoma clearly visualized; and the T/NT ratio of radioactivity the highest is 11.5 and average on 5.92. There is no positive imaging in parosteal sarcoma the technique of the radioimmunoimaging presented have those advantages: specificity and sensitivity powerful, easy to operate and harmless to health. The result of our study demonstrated biodistribution that the BMP-McAb retained in osteosarcomas tissues and indicated there are most BMP in tumor areas. It is therefore proposed that BMP are one kind of related antigen with osteosarcomas and has a satisfactory to clinical study.
作者采用骨形态发生蛋白单克隆抗体（BMP - McAb），运用放射免疫成像技术对骨肉瘤进行定位。通过氯胺T法用125I或131I标记的BMP - McAb注射给患者，并在注射抗体后24或48小时进行单光子发射计算机断层扫描（SPECT）成像。有7例骨肉瘤患者和1例骨膜骨肉瘤患者。SPECT成像结果证实骨肉瘤的肿瘤区域清晰可见；放射性的T/NT比最高为11.5，平均为5.92。骨膜肉瘤未见阳性成像。所呈现的放射免疫成像技术具有特异性和敏感性强、操作简便且对健康无害等优点。我们的研究结果表明BMP - McAb在骨肉瘤组织中保留的生物分布，并表明肿瘤区域存在最多的BMP。因此，提出BMP是一种与骨肉瘤相关的抗原，对临床研究具有一定意义。
