Farrands P A, Perkins A, Sully L, Hopkins J S, Pimm M V, Baldwin R W, Hardcastle J D
J Bone Joint Surg Br. 1983 Nov;65(5):638-40. doi: 10.1302/0301-620X.65B5.6358231.
Immunoscintigraphy using radioisotope-labelled monoclonal antibody prepared against osteosarcoma 791T cells was used to detect a primary osteosarcoma. The eight-centimetre tumour was detected using rectilinear scintigraphy of 131I-labelled antibodies. Image enhancement was achieved by subtraction of blood-pool radioactivity labelled with technetium-99m. The ratio of tumour to non-tumour uptake of radioactivity (5:1) suggested that antibody targeting of therapeutic agents is feasible.
使用针对骨肉瘤791T细胞制备的放射性同位素标记单克隆抗体进行免疫闪烁扫描，以检测原发性骨肉瘤。通过131I标记抗体的直线扫描检测到了这个8厘米的肿瘤。通过减去用锝-99m标记的血池放射性来实现图像增强。肿瘤与非肿瘤放射性摄取的比率（5:1）表明，治疗药物的抗体靶向是可行的。
