Young R C
New York Hospital-Cornell Medical Center, Westchester Division, White Plains.
Psychopharmacol Bull. 1991;27(4):521-32.
Hydroxylated metabolites (OHMs) of antidepressant drugs are pharmacologically active. On chronic administration, unconjugated OHM plasma concentrations can be substantial compared to that of the parent compound, especially for secondary amine TCAs and bupropion. OHMs may contribute to toxicity and may contribute to, or attenuate, efficacy. Direct administration of OHMs may be associated with antidepressant effects.
抗抑郁药物的羟基化代谢物（OHMs）具有药理活性。长期给药时，与母体化合物相比，未结合的OHM血浆浓度可能相当可观，尤其是对于仲胺类三环抗抑郁药和安非他酮而言。OHMs可能导致毒性，也可能促进或减弱疗效。直接给予OHMs可能会产生抗抑郁作用。
