从超免疫马抗蛇毒血清中分离IgGT：其保护能力。

Isolation of IgGT from hyperimmune horse anti-snake venom serum: its protective ability.

作者信息

Fernandes I, Takehara H A, Mota I

机构信息

Immunology Research and Training Center Otto G. Bier, Instituto Butantan, São Paulo, Brazil.

出版信息

Toxicon. 1991;29(11):1373-9. doi: 10.1016/0041-0101(91)90124-a.

DOI:10.1016/0041-0101(91)90124-a

Abstract

Hyperimmune horse anti-bothropic serum, used in serum therapy, was analyzed for its IgGT content and protective ability. IgGT was isolated through a combination of salt-mediated hydrophobic chromatography and protein A affinity chromatography. The chromatographic fractions obtained were analyzed with regard to their isotype content and protective ability. The results suggest that the protective ability of hyperimmune anti-venom serum is located mainly in the IgGT subclass.

摘要

用于血清疗法的超免疫马抗 Bothropic 血清，对其 IgGT 含量和保护能力进行了分析。通过盐介导的疏水色谱法和蛋白 A 亲和色谱法相结合的方式分离出 IgGT。对获得的色谱级分的同种型含量和保护能力进行了分析。结果表明，超免疫抗蛇毒血清的保护能力主要位于 IgGT 亚类中。

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