Picton T W, McEvoy L K, Champagne S C
Human Neuroscience Research Unit, University of Ottawa, Canada.
Acta Otolaryngol Suppl. 1991;491:139-43; discussion 144. doi: 10.3109/00016489109136791.
If an identical noise is presented to each ear with one ear receiving the noise slightly earlier than the other, the listener perceives the sound as originating from the side of the leading ear. If the interaural time-difference reverses, the subject perceives a shift in the lateralization of the sound to the other ear. This shift in lateralization evokes a late auditory potential with a negative wave at 135 ms and positive waves at 75 and 220 ms. This evoked potential specifically indexes central auditory processing since information about the timing of the auditory stimuli must be compared between the two ears. The response increases in amplitude with increasing interaural time-difference reaching maximum values between 0.3 and 1.5 ms. The response is evoked through acoustic frequencies below 2,000 Hz. In patients with multiple sclerosis the response is often abnormally delayed or small. The response may therefore be helpful in the clinical evaluation of patients with central auditory dysfunction.
如果给每只耳朵呈现相同的噪声，且一只耳朵比另一只耳朵稍早接收到噪声，聆听者会感觉声音来自领先耳朵的一侧。如果双耳时间差颠倒，受试者会感觉到声音的定位转移到了另一只耳朵。这种定位转移会诱发一种晚期听觉电位，在135毫秒时出现负波，在75毫秒和220毫秒时出现正波。这种诱发电位专门指示中枢听觉处理过程，因为必须在两只耳朵之间比较有关听觉刺激时间的信息。随着双耳时间差增加，反应幅度会增大，在0.3至1.5毫秒之间达到最大值。该反应是通过低于2000赫兹的声频诱发的。在多发性硬化症患者中，该反应通常异常延迟或幅度较小。因此，该反应可能有助于对中枢听觉功能障碍患者进行临床评估。
