Richter-Levin G, Segal M
Center for Neuroscience, Weizmann Institute, Rehovot, Israel.
Brain Res. 1991 Dec 6;566(1-2):21-5. doi: 10.1016/0006-8993(91)91676-r.
It has been previously demonstrated that an embryonic raphe grafted into a serotonin-depleted hippocampus restores normal serotonin innervation of the hippocampus and behaviors associated with serotonin. To test the possibility that the behavioral effects of these grafts result from non-specific actions of the grafted tissue or the grafting procedure itself, we compared raphe grafts with septal grafts, in serotonin-depleted rats. We also compared the effects of a serotonin synthesis inhibitor, p-chlorophenylalanine, on the behavior of normal, serotonin-depleted and raphe-grafted rats. The results indicate that the bulk of behavioral effects of raphe grafts are due to the serotonergic nature of the graft.
先前已经证明，将胚胎中缝核移植到5-羟色胺缺乏的海马体中，可恢复海马体正常的5-羟色胺神经支配以及与5-羟色胺相关的行为。为了测试这些移植的行为效应是否源于移植组织的非特异性作用或移植手术本身，我们在5-羟色胺缺乏的大鼠中，将中缝核移植与隔区移植进行了比较。我们还比较了5-羟色胺合成抑制剂对氯苯丙氨酸对正常、5-羟色胺缺乏和中缝核移植大鼠行为的影响。结果表明，中缝核移植的大部分行为效应是由于移植的5-羟色胺能特性所致。
