Mazur A W, Hiler G D, Lee S S, Armstrong M P, Wendel J D
Procter and Gamble Co., Miami Valley Laboratories, Cincinnati, OH 45239-8707.
Chem Phys Lipids. 1991 Dec;60(2):189-99. doi: 10.1016/0009-3084(91)90041-9.
A methodology for regio- and stereoselective preparation of acyl glycerol derivatives is presented. It offers easy access to specific 1,2-, 1,3-diglycerides and triglycerides as well as alkyl glycerol esters, phospholipids and glycolipids. These compounds are prepared by esterification of the corresponding glycerol derivatives such as 2-monoglycerides, alkyl glycerols, glyceryl glycosides, glyceryl phosphate esters, or unsubstituted glycerol. The regio- and stereoselectivity in the esterification is achieved by using fatty acid anhydrides and an enzymatic catalyst, 1,3-specific lipase. NMR methods for determining the regio- and stereoselectivity of esterification are discussed.
本文介绍了一种区域和立体选择性制备酰基甘油衍生物的方法。该方法能够方便地制备特定的1,2-、1,3-二甘油酯和甘油三酯，以及烷基甘油酯、磷脂和糖脂。这些化合物是通过相应甘油衍生物（如2-单甘油酯、烷基甘油、甘油糖苷、甘油磷酸酯或未取代的甘油）的酯化反应制备的。酯化反应中的区域和立体选择性是通过使用脂肪酸酐和一种酶催化剂——1,3-特异性脂肪酶来实现的。文中还讨论了用于确定酯化反应区域和立体选择性的核磁共振方法。
