二氯乙酸对超最大运动后小鼠乳酸氧化清除的影响。

Effect of dichloroacetate on oxidative removal of lactate in mice after supramaximal exercise.

Hatta H, Soma R, Atomi Y

Department of Sports Sciences, College of Arts and Sciences, University of Tokyo, Japan.

Comp Biochem Physiol B. 1991;100(3):561-4. doi: 10.1016/0305-0491(91)90220-8.

Abstract

The effect of dichloroacetate (DCA), which activates substrate oxidation on oxidative removal of lactate in mice after supramaximal exercise was investigated. 2. DCA significantly decreased the blood lactate concentration and increased the oxidative removal of lactate during prolonged exercise. 3. No significant differences were found in the removal of the blood lactate concentration, in oxidative removal of lactate after supramaximal exercise. 4. It is concluded that DCA administration which activates lactate oxidation during exercise does not activate lactate oxidation in mice after supramaximal exercise.

摘要

研究了二氯乙酸（DCA）对力竭运动后小鼠乳酸氧化清除的影响，DCA可激活底物氧化。2. DCA显著降低了长时间运动期间的血乳酸浓度，并增加了乳酸的氧化清除。3. 在力竭运动后，血乳酸浓度的清除及乳酸的氧化清除方面未发现显著差异。4. 得出的结论是，运动期间激活乳酸氧化的DCA给药在力竭运动后的小鼠中并未激活乳酸氧化。