尾状核和大脑皮质的儿茶酚胺敏感腺苷酸环化酶。鸟嘌呤核苷酸的作用。
Catecholamine-sensitive adenylate cyclase of caudate nucleus and cerebral cortex. Effects of guanine nucleotides.
作者信息
Sulakhe P V, Leung N L, Arbus A T, Sulakhe S J, Jan S H, Narayanan N
出版信息
Biochem J. 1977 Apr 15;164(1):67-74. doi: 10.1042/bj1640067.
Abstract
- GTP and GMP-P(NH)P (guanyl-5'-yl imidodiphosphate) were observed to increase the stimulation of neural adenylate cyclase by dopamine (3,4-dihydroxyphenethylamine) and noradrenaline. 2. GMP-P(NH)P had a biphasic effect on the enzyme activity. 3. Preincubation of membranes with GMP-P(NH)P activated the enzyme by a process dependent on time and temperature. Catecholamines increased the speed and the extent of this activation. 4. Membrane fractions contained high- and low-affinity sites for GMP-P(NH)P binding: this binding was due to protein(s) of the membrane preparations. 5. Low-affinity-site binding of GMP-P(NH)P appeared to be related to the stimulatory effect on the adenylate cyclase activity.
摘要
- 观察到鸟苷三磷酸（GTP）和鸟苷-5'-亚氨基二磷酸（GMP-P(NH)P）可增强多巴胺（3,4-二羟基苯乙胺）和去甲肾上腺素对神经腺苷酸环化酶的刺激作用。2. GMP-P(NH)P对该酶活性具有双相效应。3. 用GMP-P(NH)P对膜进行预孵育，通过一个依赖时间和温度的过程激活该酶。儿茶酚胺增加了这种激活的速度和程度。4. 膜组分含有与GMP-P(NH)P结合的高亲和力和低亲和力位点：这种结合归因于膜制剂中的蛋白质。5. GMP-P(NH)P的低亲和力位点结合似乎与对腺苷酸环化酶活性的刺激作用有关。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P--N--P linkage.腺苷亚氨基二磷酸，一种含有P-N-P键的三磷酸腺苷类似物。
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