Papini E, Panunzi C, Petrucci L, Picardi R, Pacella C M, Bizzarri G, Fabbrini R, Pisicchio G, Favella A, Todino M
Divisione di Medicina, Ospedale Regina Apostolorum, Albano Laziale, Roma.
Minerva Endocrinol. 1991 Oct-Dec;16(4):163-70.
Six patients affected by toxic thyroid nodules (Plummer disease) were treated by percutaneous ethanol injection (PEI). Treatment was performed injecting under ultrasound guidance 2-4 mL of 95% sterile ethyl alcohol through a spinal needle (22 gauge, 75 mm length). Treatment was performed once-twice weekly and repeated as an outpatient procedure 4-6 times. PEI induced clinical improvement and hormonal control by the end of the treatment (one month) and no complications took place. After PEI all hyperfunctioning thyroid nodules became smaller at clinical and ultrasound examination. Three months after PEI hot areas appeared cold at 99mTc and 1311 scintiscan. Serum levels of FT3, FT4, AbT, AbM, TG reached the normal range and serum TSH levels were significantly increased and responsive to TRH stimulation.
6例毒性甲状腺结节（普卢默病）患者接受了经皮乙醇注射（PEI）治疗。治疗方法是在超声引导下，通过一根脊椎穿刺针（22号，75毫米长）注入2 - 4毫升95%的无菌乙醇。治疗每周进行1 - 2次，作为门诊手术重复进行4 - 6次。PEI在治疗结束时（1个月）带来了临床改善和激素控制，且未发生并发症。PEI后，所有功能亢进的甲状腺结节在临床和超声检查中均变小。PEI后3个月，在99mTc和131I闪烁扫描中，热区变为冷区。血清FT3、FT4、AbT、AbM、TG水平达到正常范围，血清TSH水平显著升高且对TRH刺激有反应。
