Livraghi T, Ferrari C, Paracchi A, Reschini E, Macchi R M, Ciocia G L, Pirola P
Servizio di Radiologia, Ospedale Civile di Vimercate, Milano.
Minerva Endocrinol. 1993 Dec;18(4):187-9.
We treated with PEI 81 patients carriers of autonomous thyroid nodule, 65 toxic and 16 non toxic, all with undetectable serum TSH and suppressed extranodular tissue on scintigraphy. The treatment schedule was: 1-2 sessions per week, 1-8 ml per session, 3-13 sessions in total, In relation to the size and the therapeutic response. The signs of hyperthyroidism disappeared in all cases. Complete cure was obtained in 51 patients; hormonal remission was obtained in 24 patients; partial compensation was obtained in six patients. No recurrences were observed, but two dysphonias lasting three months were reported. PEI seems to be an alternative to surgery and 131I for the ablation of toxic nodules with a volume less than 30 ml.
我们用聚乙烯亚胺（PEI）治疗了81例自主性甲状腺结节携带者，其中65例为毒性结节，16例为非毒性结节，所有患者血清促甲状腺激素（TSH）均检测不到，且闪烁扫描显示结节外组织受抑制。治疗方案为：根据结节大小和治疗反应，每周1 - 2次，每次1 - 8毫升，共3 - 13次。所有病例中甲亢症状均消失。51例患者完全治愈；24例患者激素水平缓解；6例患者部分代偿。未观察到复发情况，但报告有2例出现持续3个月的声音嘶哑。对于体积小于30毫升的毒性结节，PEI似乎是手术和碘 - 131消融治疗的替代方法。
