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澳大利亚有袋类动物、胎盘哺乳动物和一种单孔目动物的血液皮质类固醇。

Blood corticosteroids in Australian marsupial and placental mammals and one monotreme.

作者信息

Oddie C J, Blaine E H, Bradshaw S D, Coghlan J P, Denton D A, Nelson J F, Scoggins B A

出版信息

J Endocrinol. 1976 Jun;69(3):341-8. doi: 10.1677/joe.0.0690341.

DOI:10.1677/joe.0.0690341
PMID:181514
Abstract

Peripheral blood corticosteroid levels were determined in nine species of Australian marsupial (Eastern grey kangaroo, black-tailed, Bennett's and pademelon wallabies, quokka, wombat, koala and Western native and tiger cats), one species of monotreme (echidna) and one placental Australian mammal (dingo). Animals were obtained or bled with minimal disturbance and came from areas considered to have adequate sodium content of the vegetation. Aldosterone, corticosterone, cortisol, 11-deoxycorticosterone and 11-deoxycortisol were measured and levels found to be similar to five introduced eutherian species (sheep, cow, dog, fox and man) with the exception of the koala and the wombat. Cortisol was the predominant corticosteroid, except in the koala, which produced corticosterone in relatively the greatest quantity, and the wombat which produced more 11-deoxycortisol. Steroid levels were generally low in the wombat. ACTH administered to the koala changed its pattern of corticosteroid secretion from predominantly corticosterone to cortisol. In the dingo, administration of ACTH caused rises in corticosteroid levels similar to those seen in most other eutherian mammals.

摘要

测定了9种澳大利亚有袋动物(东部灰袋鼠、黑尾袋鼠、贝内特氏小袋鼠、赤褐小袋鼠、短尾矮袋鼠、袋熊、树袋熊以及西部本土猫和袋狮)、1种单孔目动物(针鼹)和1种澳大利亚有胎盘哺乳动物(澳洲野狗)的外周血皮质类固醇水平。动物获取或采血时受到的干扰最小,且来自植被钠含量充足的地区。测量了醛固酮、皮质酮、皮质醇、11 - 脱氧皮质酮和11 - 脱氧皮质醇,发现除树袋熊和袋熊外,其水平与5种引入的真兽类物种(绵羊、牛、狗、狐狸和人类)相似。皮质醇是主要的皮质类固醇,但树袋熊相对产生皮质酮的量最大,袋熊产生较多的11 - 脱氧皮质醇。袋熊的类固醇水平通常较低。给树袋熊注射促肾上腺皮质激素后,其皮质类固醇分泌模式从主要分泌皮质酮转变为分泌皮质醇。在澳洲野狗中,注射促肾上腺皮质激素导致皮质类固醇水平升高,与大多数其他真兽类哺乳动物相似。

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