血清抑制素B浓度作为预测无精子症患者睾丸活检中精子获取情况的预后因素。

Serum inhibin B concentration as a prognostic factor for prediction of sperm retrieval in testis biopsy of patients with azoospermia.

作者信息

Nowroozi Mohammad-Reza, Radkhah Keivan, Ayati Mohsen, Jamshidian Hassan, Ranjbaran Alireza, Jabalameli Parviz

机构信息

Department of Urology, Imam Khomeini General Hospital, Medical Sciences/Tehran University, Tehran, Iran.

出版信息

Arch Iran Med. 2008 Jan;11(1):54-6.

PMID:18154424

Abstract

BACKGROUND

This study was conducted to determine if serum inhibin B concentration can predict spermatogenesis in azoospermic infertile men.

METHODS

This cross-sectional study included 70 patients with male-factor infertility referred to Alvand and Vali-e-Asr Infertility Centers, Tehran, Iran. All patients had azoospermia. Standard evaluation consisted of history and physical examination with extreme attention to sexual history and testis examination including testis size, consistency, and presence of varicocele. Laboratory evaluation done for all cases consisted of FSH, testosterone, LH, prolactin, and inhibin B. Testis biopsy was performed in all cases with acceptable testis volume and FSH. The mean inhibin B level was compared in groups with positive and negative sperm retrieval.

RESULTS

The mean+/-SEM age of 70 azoospermic patients was 32.1+/-6.2 (range: 20 - 50) years. All couples had primary infertility with a mean+/-SEM duration of infertility of 74.3+/-7.7 months. The mean+/-SEM testicular volume was 10.14+/-0.75 mL. The mean+/-SEM FSH and LH levels were 17.55+/-1.68, and 11.33+/-0.99 mIU/mL, respectively. The mean+/-SEM serum prolactin and testosterone levels were 308.77+/-17.35 and 5.45+/-0.91 ng/dL, respectively. The mean+/-SEM serum inhibin B concentration was 138.23+/-28.58 (range: 15 - 1500) pg/mL. Sperm was not retrieved in 82% of the patients; in 13% of the cases, biopsy revealed spermatogenesis. The mean+/-SEM serum FSH level of positive and negative groups was 9.78+/-2.13 and 22.56+/-2.46 mIU/mL, respectively (P<0.05). The mean serum LH, prolactin, and testosterone levels were not statistically different between the two groups. The mean+/-SEM serum inhibin B was 129+/-45.46, and 158.93+/-47.24 pg/mL in positive and negative groups, respectively (P>0.05).

CONCLUSION

Inhibin B concentration is not an appropriate predicting factor for testicular spermatogenesis.

摘要

背景

本研究旨在确定血清抑制素B浓度能否预测无精子症不育男性的精子发生情况。

方法

这项横断面研究纳入了70例转诊至伊朗德黑兰阿尔万德和瓦利 - 阿斯尔不孕不育中心的男性因素不孕症患者。所有患者均为无精子症。标准评估包括病史和体格检查，特别关注性病史以及睾丸检查，包括睾丸大小、质地和精索静脉曲张情况。所有病例均进行了实验室评估，包括卵泡刺激素（FSH）、睾酮、黄体生成素（LH）、催乳素和抑制素B。对所有睾丸体积和FSH水平可接受的病例进行了睾丸活检。比较了精子获取阳性和阴性组的抑制素B平均水平。

结果

70例无精子症患者的平均年龄±标准误为32.1±6.2（范围：20 - 50）岁。所有夫妇均为原发性不孕，平均不孕时间±标准误为74.3±7.7个月。平均睾丸体积±标准误为10.14±0.75 mL。平均FSH和LH水平分别为17.55±1.68和11.33±0.99 mIU/mL。血清催乳素和睾酮的平均水平±标准误分别为308.77±17.35和5.45±0.91 ng/dL。血清抑制素B的平均浓度±标准误为138.23±28.58（范围：15 - 1500）pg/mL。82%的患者未获取到精子；13%的病例活检显示有精子发生。精子获取阳性和阴性组的平均血清FSH水平±标准误分别为9.78±2.13和22.56±2.46 mIU/mL（P<0.05）。两组间血清LH、催乳素和睾酮的平均水平无统计学差异。精子获取阳性和阴性组的血清抑制素B平均水平±标准误分别为129±45.46和158.93±47.24 pg/mL（P>0.05）。