Moradi Mahmoudreza, Alemi Mohsen, Moradi Asaad, Izadi Babak, Parhodah Farajollah, Torkaman Asadi Fatemeh
Infertility Research Center, Urology-Nephrology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Pathology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Iran J Reprod Med. 2012 May;10(3):243-8.
In the recent years, the use of laboratory blood factors such as FSH and inhibin-B for the assessment of spermatogenesis in different studies has increased; of course, the conflicting results have also been achieved.
To investigate if the measurement of inhibin-B can help surgeon to reduce unnecessary diagnostic testicular biopsies in males with azoospermia.
This cross-sectional study was done during July 2006 to September 2007 on 41 patients with azoospermia. FSH and inhibin-B were measured and bilateral open testicular biopsy was performed for all patients.
Sperm was seen in 29% of biopsies that in 100% of these samples inhibin-B was more than 100 pg/mL and FSH was less than twice the normal (p=0.001). Inhibin-B had significant correlation inversely with testicular fibrosis and Sertoli cell only syndrome (p=0.043 and p=0.011, respectively) and directly with incomplete spermatocytic maturation arrest and obstructive azoospermia (p=0.027 and p=0.013, respectively). FSH was only correlated with obstructive azoospermia (p=0.001).
We suggest that if FSH is less than twice the normal, inhibin-B should be measured and if its level is less than 100 pg/mL, we can cancel about the half of unnecessary diagnostic testicular biopsies.
近年来，在不同研究中使用实验室血液因子如促卵泡激素（FSH）和抑制素B来评估精子发生的情况有所增加；当然，也取得了相互矛盾的结果。
探讨抑制素B的测量是否有助于外科医生减少无精子症男性不必要的诊断性睾丸活检。
本横断面研究于2006年7月至2007年9月对41例无精子症患者进行。测量了FSH和抑制素B，并对所有患者进行了双侧开放性睾丸活检。
在29%的活检样本中发现了精子，在这些样本中，100%的抑制素B超过100 pg/mL且FSH低于正常水平的两倍（p = 0.001）。抑制素B与睾丸纤维化和唯支持细胞综合征呈显著负相关（分别为p = 0.043和p = 0.011），与不完全精子细胞成熟停滞和梗阻性无精子症呈显著正相关（分别为p = 0.027和p = 0.013）。FSH仅与梗阻性无精子症相关（p = 0.001）。
我们建议，如果FSH低于正常水平的两倍，应测量抑制素B，如果其水平低于100 pg/mL，我们可以取消大约一半不必要的诊断性睾丸活检。
