Kumanov Philip, Nandipati Kalyana, Tomova Analia, Agarwal Ashok
Clinical Centre of Endocrinology and Gerontology, Medical University, Sofia, Bulgaria.
Fertil Steril. 2006 Aug;86(2):332-8. doi: 10.1016/j.fertnstert.2006.01.022. Epub 2006 Jun 9.
To assess the role of inhibin B in the evaluation of male factor infertility.
Prospective study.
Reproductive endocrinology clinic.
PATIENT(S): Seventy-five patients with infertility problems (mean age 31.2 +/- 7.5 years) and 12 controls (32.1 +/- 8.8 years) with proven fertility.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Semen analysis was performed according to World Health Organization guidelines. Testicular volume was assessed with the Prader's orchidometer. Serum levels of inhibin B (pg/mL), LH (mIU/mL), FSH (mIU/mL), prolactin (micro IU/mL), and testosterone (nmol/L) were assessed.
RESULT(S): The mean +/- SEM inhibin B and testosterone levels were significantly lower in the patients than in the controls (inhibin B: 116.4 +/- 11.7 vs. 181.2 +/- 20.9, P=.008; testosterone: 13.6 +/- 0.9 vs. 25.1 +/- 2.9, P=.008). In general, sperm count and testicular volume in the patients were significantly and positively correlated with inhibin B (sperm count: r = 0.476, P<.0001; testicular volume, right: r = 0.57, P=.0001; left: r = 0.53, P=.0001); the inhibin B-FSH index was negatively correlated with FSH. Inhibin B was more strongly correlated with testicular volume and semen parameters than FSH. Inhibin B in the patients was negatively correlated with FSH (r = -0.723, P=.0001) and LH (r = -0.52, P=.0001) and was positively correlated with testosterone (r = 0.4, P=.0013).
CONCLUSION(S): Inhibin B measurement is a better marker of fertility status than FSH and LH. Concentration of inhibin B in patients with infertility may provide useful information on spermatogenesis and possibly serve as a more direct marker of spermatogenesis than FSH.
评估抑制素B在男性因素不育评估中的作用。
前瞻性研究。
生殖内分泌诊所。
75例有不育问题的患者（平均年龄31.2±7.5岁）和12例已证实有生育能力的对照者（32.1±8.8岁）。
无。
根据世界卫生组织指南进行精液分析。用普拉德睾丸测量器评估睾丸体积。评估血清抑制素B（pg/mL）、促黄体生成素（mIU/mL）、促卵泡生成素（mIU/mL）、催乳素（μIU/mL）和睾酮（nmol/L）水平。
患者的平均±标准误抑制素B和睾酮水平显著低于对照者（抑制素B：116.4±11.7 vs. 181.2±20.9，P = 0.008；睾酮：13.6±0.9 vs. 25.1±2.9，P = 0.008）。总体而言，患者的精子计数和睾丸体积与抑制素B显著正相关（精子计数：r = 0.476，P < 0.0001；睾丸体积，右侧：r = 0.57，P = 0.0001；左侧：r = 0.53，P = 0.0001）；抑制素B - 促卵泡生成素指数与促卵泡生成素呈负相关。抑制素B与睾丸体积和精液参数的相关性比促卵泡生成素更强。患者体内的抑制素B与促卵泡生成素（r = -0.723，P = 0.0001）和促黄体生成素（r = -0.52，P = 0.0001）呈负相关，与睾酮呈正相关（r = 0.4，P = 0.0013）。
与促卵泡生成素和促黄体生成素相比，测量抑制素B是生育状态更好的标志物。不育患者体内抑制素B的浓度可能为生精作用提供有用信息，并且可能是比促卵泡生成素更直接的生精标志物。
