胰高血糖素对大鼠肝脏和附睾脂肪垫组织中环磷酸腺苷水平的品系差异影响。
Rat strain differences in cyclic-AMP levels in liver and epididymal fat pad tissue as influenced by glucagon.
作者信息
Gardner L B, Spannhake E B, Reisher S
出版信息
J Nutr. 1976 Aug;106(8):1102-7. doi: 10.1093/jn/106.8.1102.
A glucagon-saline solution (0.1 ml, 10(7) mole/100 g body weight) was injected via the portal vein into nonfasted Wistar and carbohydrate-sensitive BHE rats. Levels of liver and epididymal fat pad cyclic-AMP were observed after 6 and 24 minutes. When compared to sham injected rats at 6 minutes, glucagon injected rats of both strains had twice the level of cyclie-AMP in liver and fat pad tissue. By 24 minutes, the cyclic-AMP levels of the Wistar rats had decreased to those observed in their sham injected counterparts, and the concentration of liver cyclic-AMP in both sham injected and glucagon injected BHE rats had decreased to levels significantly below those observed in the Wistar rats. This observation suggests that a lipolytic-lipogenic imbalance may reside in the livers of rats of the BHE strain.
将胰高血糖素 - 盐溶液（0.1毫升，10⁷摩尔/100克体重）经门静脉注入未禁食的Wistar大鼠和对碳水化合物敏感的BHE大鼠体内。在6分钟和24分钟后观察肝脏和附睾脂肪垫中环状AMP的水平。与6分钟时假注射的大鼠相比，两种品系的胰高血糖素注射大鼠肝脏和脂肪垫组织中的环状AMP水平均为其两倍。到24分钟时，Wistar大鼠的环状AMP水平已降至假注射对照大鼠的水平，而假注射和胰高血糖素注射的BHE大鼠肝脏中的环状AMP浓度均降至显著低于Wistar大鼠的水平。这一观察结果表明，BHE品系大鼠的肝脏中可能存在脂解 - 脂肪生成失衡。
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