3':5'-环磷酸腺苷对大鼠脂肪细胞葡萄糖转运的影响。
Effect of 3':5'-cyclic AMP on glucose transport in rat adipocytes.
作者信息
Taylor W M, Mak M L, Halperin M L
出版信息
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4359-63. doi: 10.1073/pnas.73.12.4359.
Abstract
An indirect method for obtaining a reliable measure of the rate of glucose transport into adipocytes is described. Evidence is presented that altered levels of 3':5'-cyclic AMP can influence the transport of glucose into adipocytes. When cyclic AMP levels were lowered with antilipolytic agents (insulin, nicotinic acid, or clofibrate), rates of glucose transport were increased. In contrast, when adipose tissue levels of cyclic AMP were elevated by lipolytic hormones or theophylline, glucose transport when cyclic AMP levels were elevated by lipolytic agents. Agents that can raise cyclic AMP but inhibit lipolytic (procaine, amitryptyline, and phenylethylbiguanide) reduced the rate of glucose transport. Other data are presented that are consistent with the conclusion that cyclic AMP inhibits glucose transport into adipocytes.
摘要
本文描述了一种间接方法，用于可靠地测量葡萄糖转运到脂肪细胞中的速率。有证据表明，3':5'-环磷酸腺苷（3':5'-cyclic AMP）水平的改变会影响葡萄糖转运到脂肪细胞中的过程。当使用抗脂解剂（胰岛素、烟酸或氯贝丁酯）降低环磷酸腺苷水平时，葡萄糖转运速率增加。相反，当脂解激素或茶碱使脂肪组织中环磷酸腺苷水平升高时，脂解剂使环磷酸腺苷水平升高时的葡萄糖转运情况。能升高环磷酸腺苷但抑制脂解的药物（普鲁卡因、阿米替林和苯乙双胍）降低了葡萄糖转运速率。还提供了其他数据，这些数据与环磷酸腺苷抑制葡萄糖转运到脂肪细胞中的结论一致。
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Proc Natl Acad Sci U S A. 1976 Dec;73(12):4359-63. doi: 10.1073/pnas.73.12.4359.
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