超广谱β-内酰胺酶：结构与动力学机制
Extended-spectrum beta-lactamases: structure and kinetic mechanism.
作者信息
Page M G P
机构信息
Basilea Pharmaceutica Ltd, Basel, Switzerland.
出版信息
Clin Microbiol Infect. 2008 Jan;14 Suppl 1:63-74. doi: 10.1111/j.1469-0691.2007.01863.x.
Abstract
Recent years have seen an explosion in the numbers of extented spectrum class A beta-lactamases (ESBLs). The steady-state kinetic parameters for hydrolysis of beta-lactams by ESBLs is discussed in the light of what is known about the structure of these mutant enzymes.
摘要
近年来，超广谱A类β-内酰胺酶（ESBLs）的数量急剧增加。鉴于对这些突变酶结构的了解，本文讨论了ESBLs水解β-内酰胺的稳态动力学参数。
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