Li Lin-Feng
Department of Dermatology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100083, China.
Contact Dermatitis. 2008 Jan;58(1):24-7. doi: 10.1111/j.1600-0536.2007.01251.x.
The prevalence of sensitization to cocamidopropyl betaine (CAPB) in China has not been reported.
This study is to evaluate the prevalence of CAPB sensitization in patients patch tested in Peking University Third Hospital, Beijing.
429 consecutive patients with suspected allergic contact dermatitis were patch tested with CAPB 1.0% aqueous, 3-dimethylaminopropylamine (DMAPA) 1.0% aqueous as well as a modified European standard series of allergens from June 2005 to August 2006.
42 patients (9.8%) had a positive reaction to CAPB. 25 of them (59.5%) were considered relevant. Of those, 7 were head and/or neck dermatitis, 4 hand dermatitis, 1 cheilitis, and the other 13 patients were widespread dermatitis. 10 out of 429 (2.3%) patients reacted to DMAPA. Of those, 8 were relevant and 6 of them also reacted to CAPB.
The rate of CAPB sensitization in our study is higher than previously reported elsewhere. CAPB is a common cosmetic allergen in Beijing. Both CAPB and DMAPA should be tested in patients with suspected cosmetic dermatitis.
中国对椰油酰胺丙基甜菜碱（CAPB）致敏的患病率尚无报道。
本研究旨在评估在北京北京大学第三医院接受斑贴试验的患者中CAPB致敏的患病率。
2005年6月至2006年8月，连续429例疑似过敏性接触性皮炎患者接受了1.0% CAPB水溶液、1.0% 3 - 二甲基氨基丙胺（DMAPA）水溶液以及改良欧洲标准变应原系列的斑贴试验。
42例患者（9.8%）对CAPB有阳性反应。其中25例（59.5%）被认为具有相关性。其中，7例为头颈部皮炎，4例为手部皮炎，1例为唇炎，其他13例为泛发性皮炎。429例患者中有10例（2.3%）对DMAPA有反应。其中8例具有相关性，且其中6例对CAPB也有反应。
我们研究中CAPB致敏率高于其他地方先前报道的。CAPB是北京常见的化妆品变应原。对于疑似化妆品皮炎患者，应同时检测CAPB和DMAPA。
