Division of Dermatology, Hanamizuki Clinic, Ushiku, Ibaraki, Japan.
Division of Gynecology, Hanamizuki Clinic, Ushiku, Ibaraki, Japan.
Contact Dermatitis. 2023 Nov;89(5):368-373. doi: 10.1111/cod.14393. Epub 2023 Aug 7.
The allergen responsible for cocamidopropyl betaine (CAPB) allergies has been debated.
To investigate the sensitizing agents of CAPB, the patch test positivity rates of impurities were examined in Japanese patients with CAPB-related allergic contact dermatitis.
Thirty patients with scalp dermatitis and positive patch tests for CAPB and/or lauramidopropyl betaine (LAPB) were enrolled in this study. They were patch tested with the detergents that they had been using at the time of their first visit and with the impurities dimethylaminopropylamine (DMAPA) and lauramidopropyl dimethylamine (LAPDMA).
The positivity rate in patch tests of the 37 detergents that the patients had been using was 78.4% (29/37). The positivity rates of DMAPA 1% pet., 1% aq. and 0.2% aq. were 32.1% (9/28), 14.3% (4/28) and 13.3% (4/30), respectively, whereas those of LAPDMA 0.1% and 0.05% were 30.0% (9/30) and 16.7% (5/30), respectively. Among the 30 patients, 6 exhibited positive results for both DMAPA and LAPDMA, 3 showed positive results for DMAPA alone and 6 produced positive results for LAPDMA alone.
Patch tests produced an overall positivity rate for DMAPA, LAPDMA or both of 50.0% (15/30) in patients with scalp dermatitis and positive patch test results for CAPB and/or LAPB.
引起椰油酰胺丙基甜菜碱（CAPB）过敏的过敏原一直存在争议。
为了研究 CAPB 的致敏剂，本研究检测了 CAPB 相关变应性接触性皮炎日本患者中杂质的斑贴试验阳性率。
本研究纳入了 30 例头皮炎且 CAPB 和/或月桂酰胺丙基甜菜碱（LAPB）斑贴试验阳性的患者。他们用首次就诊时正在使用的清洁剂以及杂质二甲氨基丙基胺（DMAPA）和月桂酰胺丙基二甲胺（LAPDMA）进行斑贴试验。
患者正在使用的 37 种清洁剂的斑贴试验阳性率为 78.4%（29/37）。DMAPA 1% pet.、1% aq.和 0.2% aq.的阳性率分别为 32.1%（28/28）、14.3%（28/28）和 13.3%（30/30），而 LAPDMA 0.1%和 0.05%的阳性率分别为 30.0%（30/30）和 16.7%（30/30）。在 30 例患者中，6 例同时对 DMAPA 和 LAPDMA 呈阳性，3 例仅对 DMAPA 呈阳性，6 例仅对 LAPDMA 呈阳性。
头皮炎且 CAPB 和/或 LAPB 斑贴试验阳性的患者中，DMAPA、LAPDMA 或两者的斑贴试验阳性率总体为 50.0%（15/30）。
