Izcue Ana, Powrie Fiona
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Immunology. 2008 Jan;123(1):6-10. doi: 10.1111/j.1365-2567.2007.02778.x.
Tolerance to self and harmless antigens is one of the central features of the immune system, and it is obtained through a combination of multiple mechanisms. Discriminating between pathogens and non-pathogenic antigens is especially important in the intestine, which constitutes the main contact surface between the body and the outside environment. Recently, the role of Foxp3+ regulatory T cells (Treg) in the establishment and maintenance of tolerance has been the focus of numerous studies. In this review, we briefly discuss the historical background leading to the identification of Foxp3+ Treg and give an overview of their role in controlling systemic and mucosal immune responses.
对自身和无害抗原的耐受性是免疫系统的核心特征之一，它是通过多种机制共同作用而获得的。区分病原体和非致病性抗原在肠道中尤为重要，因为肠道是人体与外界环境的主要接触界面。最近，Foxp3+调节性T细胞（Treg）在耐受性建立和维持中的作用一直是众多研究的焦点。在这篇综述中，我们简要讨论了导致Foxp3+ Treg被识别的历史背景，并概述了它们在控制全身和黏膜免疫反应中的作用。
