特殊调节性T细胞综述：调节性T细胞与肠道——守卫前沿阵地
Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier.
作者信息
Izcue Ana, Powrie Fiona
机构信息
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
出版信息
Immunology. 2008 Jan;123(1):6-10. doi: 10.1111/j.1365-2567.2007.02778.x.
Abstract
Tolerance to self and harmless antigens is one of the central features of the immune system, and it is obtained through a combination of multiple mechanisms. Discriminating between pathogens and non-pathogenic antigens is especially important in the intestine, which constitutes the main contact surface between the body and the outside environment. Recently, the role of Foxp3+ regulatory T cells (Treg) in the establishment and maintenance of tolerance has been the focus of numerous studies. In this review, we briefly discuss the historical background leading to the identification of Foxp3+ Treg and give an overview of their role in controlling systemic and mucosal immune responses.
摘要
对自身和无害抗原的耐受性是免疫系统的核心特征之一，它是通过多种机制共同作用而获得的。区分病原体和非致病性抗原在肠道中尤为重要，因为肠道是人体与外界环境的主要接触界面。最近，Foxp3+调节性T细胞（Treg）在耐受性建立和维持中的作用一直是众多研究的焦点。在这篇综述中，我们简要讨论了导致Foxp3+ Treg被识别的历史背景，并概述了它们在控制全身和黏膜免疫反应中的作用。
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Nat Immunol. 2007 Sep;8(9):931-41. doi: 10.1038/ni1504. Epub 2007 Aug 12.
2
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.小肠固有层树突状细胞通过视黄酸促进Foxp3调节性T细胞的从头生成。
J Exp Med. 2007 Aug 6;204(8):1775-85. doi: 10.1084/jem.20070602. Epub 2007 Jul 9.
3
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism.一群功能特化的黏膜CD103⁺树突状细胞通过转化生长因子-β和视黄酸依赖机制诱导Foxp3⁺调节性T细胞。
J Exp Med. 2007 Aug 6;204(8):1757-64. doi: 10.1084/jem.20070590. Epub 2007 Jul 9.
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