特殊调节性T细胞综述：免疫反应的调节——审视T细胞的作用。
Special regulatory T-cell review: Regulation of immune responses--examining the role of T cells.
作者信息
Simpson Elizabeth
机构信息
Immunology Department, Faculty of Medicine, Imperial College, London, UK.
出版信息
Immunology. 2008 Jan;123(1):13-6. doi: 10.1111/j.1365-2567.2007.02775.x.
Abstract
The history of regulatory T cells goes back to the realisation that T cells could provide 'help' for antibody responses: the obverse of this is their ability to hold them in check. This brief personal overview follows the initial designation of T cells as 'suppressor' and the various hypotheses, some now disproved, put forward for their mechanism of action. We now cautiously label them T regulatory cells, but realise they do not control not all immune regulation. They probably operate through several mechanisms, and some of these are discussed.
摘要
调节性T细胞的历史可以追溯到人们认识到T细胞能够为抗体反应提供“帮助”：反之，它们也有抑制抗体反应的能力。这篇简短的个人综述追溯了T细胞最初被命名为“抑制细胞”的过程，以及为其作用机制提出的各种假说，其中一些现在已被推翻。我们现在谨慎地将它们标记为调节性T细胞，但也认识到它们并不掌控所有的免疫调节。它们可能通过多种机制发挥作用，本文将对其中一些机制进行讨论。
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2
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