Pierce C W, Kapp J A
Agents Actions Suppl. 1980;7:126-33.
Suppressor T cells modulate both humoral and cell-mediated immune responses by antigen-specific and nonspecific mechanisms. Moreover, soluble factors either secreted by or extracted from these suppressor T cells efficiently mediate the immunoregulatory activities of these cells. The molecular properties and mechanism(s) of action of a nonspecific and an antigen-specific suppressor T-cell factor, both of which regulate antibody responses, will be compared and contrasted. The nonspecific factor, soluble immune response suppressor (SIRS), is produced by Concanavalin A-stimulated T cells and is not separable from MIF activity. The antigen-specific suppressor factor (GAT-TsF) is extracted from T cells stimulated with the synthetic terpolyper L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). These two factors differ markedly in molecular properties, target cells and mechanism(s) of action. The comparison of the mechanism(s) of action of nonspecific and antigen-specific suppressor T-cell factors provides useful insights into the various pathways operative for regulation of antibody responses. The understanding of the interrelationships among these two classes of immunoregulatory molecules and how they may act to modulate antibody responses are essential for therapeutic manipulation of immune responses and control of the inflammatory response. This is especially important with the nonspecific factor, SIRS, and provides a model in which to study the interface of immune responses and inflammatory responses.
抑制性T细胞通过抗原特异性和非特异性机制调节体液免疫和细胞介导的免疫反应。此外，由这些抑制性T细胞分泌或提取的可溶性因子可有效介导这些细胞的免疫调节活性。将对两种调节抗体反应的非特异性和抗原特异性抑制性T细胞因子的分子特性和作用机制进行比较和对比。非特异性因子，即可溶性免疫反应抑制因子（SIRS），由刀豆蛋白A刺激的T细胞产生，且与巨噬细胞移动抑制因子（MIF）活性不可分离。抗原特异性抑制因子（GAT-TsF）是从用合成三聚体L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）刺激的T细胞中提取的。这两种因子在分子特性、靶细胞和作用机制上有显著差异。对非特异性和抗原特异性抑制性T细胞因子作用机制的比较，为调节抗体反应的各种作用途径提供了有用的见解。了解这两类免疫调节分子之间的相互关系以及它们如何调节抗体反应，对于免疫反应的治疗性调控和炎症反应的控制至关重要。对于非特异性因子SIRS来说尤其重要，它提供了一个研究免疫反应和炎症反应界面的模型。
