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北欧国家辅助生殖技术生育的人口统计学。

The demographics of assisted reproductive technology births in a Nordic country.

机构信息

Centre for Longitudinal Studies, Department of Social Science, University College London, London, UK.

Max Planck Institute for Demographic Research, Rostock, Germany.

出版信息

Hum Reprod. 2020 Jun 1;35(6):1441-1450. doi: 10.1093/humrep/deaa055.

Abstract

STUDY QUESTION

What are the socio-demographic characteristics of families in Norway who have children after assisted reproductive technology (ART), and have these characteristics changed over time?

SUMMARY ANSWER

Parents who conceive through ART in Norway tend to be advantaged families, and their socio-demographic profile has not changed considerably over the period 1985-2014.

WHAT IS KNOWN ALREADY

A small number of studies show that couples who conceive through ART tend to be socio-economically advantaged.

STUDY DESIGN, SIZE, DURATION: Norwegian Population Register, the Medical Birth Register and the national data bases were linked to study all live births in Norway between 1985 and 2014.

PARTICIPANTS/MATERIALS, SETTING, METHODS: The sample consisted of 1 757 768 live births. Simple bivariate analyses were performed to describe the socio-demographic characteristics of parents who conceived through ART and changes in these characteristics over the time period 1985-2014. We used linear probability models to estimate the association between parental income and giving birth after ART from 2000 to 2014, before and after adjustment for maternal age at delivery, education and area of residence.

MAIN RESULTS AND THE ROLE OF CHANCE

Parents conceiving through ART were more likely to be older, with the highest levels of income and education, and married. Their socio-demographic profiles did not change considerably during the period 1985-2014. In the unadjusted model, parents belonging to the top income quartile were 4.2 percentage points more likely (95% CI: 4.1 to 4.3) to have conceived through ART than parents who belonged to the bottom income quartile. Adjustment for maternal age only partially reduced the income disparities (for the top income quartile by 35% (β = 2.7 with 95% CI: 2.5 to 2.8)). Additional adjustment for maternal education, marital status and area of residence did not further attenuate the associations.

LIMITATIONS, REASONS FOR CAUTION: The data does not enable us to tell whether the lower numbers of children conceived through ART amongst more disadvantaged individuals is caused by lower success rates with ART treatment, lower demand of ART services or barriers faced in access to ART. The study focuses on Norway, a context characterised by high subsidisation of ART services.

WIDER IMPLICATIONS OF THE FINDINGS

Even though in Norway access to ART services is highly subsidised, the results highlight important and persisting social inequities in use of ART. The results also indicate that children born after ART grow up in resourceful environments, which will benefit their development and well-being.

STUDY FUNDING/COMPETING INTEREST(S): This work was supported by European Research Council agreement n. 803959 (to A.G.), by Economic and Social Research Council grant ES/M001660/1 and by the Research Council of Norway through its Centres of Excellence funding scheme, project number 262700. The authors have no conflict of interest to declare.

TRIAL REGISTRATION NUMBER

Not applicable.

摘要

研究问题

挪威通过辅助生殖技术(ART)生育的家庭的社会人口学特征是什么?这些特征是否随时间发生了变化?

总结答案

在挪威,通过 ART 受孕的父母往往来自优势家庭,他们的社会人口学特征在 1985 年至 2014 年间并没有发生显著变化。

已知情况

少数研究表明,通过 ART 受孕的夫妇往往具有社会经济优势。

研究设计、规模、持续时间:挪威人口登记处、医疗出生登记处和国家数据库被链接起来,以研究 1985 年至 2014 年期间挪威所有的活产儿。

参与者/材料、设置、方法:样本包括 1757768 例活产儿。简单的双变量分析用于描述通过 ART 受孕的父母的社会人口学特征,并描述这些特征在 1985 年至 2014 年期间的变化。我们使用线性概率模型来估计从 2000 年到 2014 年父母收入与 ART 后生育之间的关联,在调整了母亲分娩时的年龄、教育程度和居住地区后。

主要结果和机会作用

通过 ART 受孕的父母更有可能年龄较大,收入和教育水平较高,并且已婚。他们的社会人口学特征在 1985 年至 2014 年间并没有发生显著变化。在未调整的模型中,属于最高收入四分位数的父母通过 ART 受孕的可能性比属于最低收入四分位数的父母高 4.2 个百分点(95%置信区间:4.1 至 4.3)。仅对母亲年龄进行调整部分降低了收入差距(对于最高收入四分位数,降低了 35%(β=2.7,95%置信区间:2.5 至 2.8))。对母亲教育、婚姻状况和居住地区的进一步调整并没有进一步减弱关联。

局限性、谨慎的原因:这些数据并不能说明在处于劣势的个体中,通过 ART 受孕的儿童数量较少是由于 ART 治疗成功率较低、对 ART 服务的需求较低还是获得 ART 服务的障碍造成的。本研究侧重于挪威,这是一个 ART 服务高度补贴的背景。

研究结果的更广泛影响

即使在挪威,ART 服务的获得得到了高度补贴,但研究结果仍突出了使用 ART 方面存在的重要且持续存在的社会不平等。研究结果还表明,通过 ART 出生的儿童在资源丰富的环境中成长,这将有益于他们的发展和福祉。

研究资金/利益冲突:这项工作得到了欧洲研究理事会协议 n. 803959(授予 A.G.)、经济和社会研究理事会拨款 ES/M001660/1 以及挪威研究理事会通过其卓越中心资助计划的支持,项目编号为 262700。作者没有利益冲突需要声明。

试验注册编号

不适用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b47e/7316497/17ff91bd8e6a/deaa055f1.jpg

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