Alió Jorge L, Muftuoglu Orkun, Ortiz Dolores, Artola Alberto, Pérez-Santonja Juan Jose, de Luna Gracia Castro, Abu-Mustafa Sabat K, Garcia Maria Jose
Vissum Department of Refractive Surgery and Division of Ophthalmology, Instituto Oftalmológico de Alicante, Miguel Hernandez University, Medical School, Alicante, Spain.
Am J Ophthalmol. 2008 Jan;145(1):37-45. doi: 10.1016/j.ajo.2007.09.009.
To evaluate the long-term outcomes of excimer laser myopic photorefractive keratectomy (PRK) for myopia higher than -6 diopters (D).
A long-term (10-year) follow-up retrospective, interventional case series.
The study included 267 eyes of 191 patients with myopia with spherical equivalent (SE) of more than -6 D treated with myopic PRK at the Instituto Oftalmológico de Alicante, Alicante, Spain, using the VISX 20/20 excimer laser (Santa Clara, California, USA). All patients were evaluated three months, one year, two years, five years, and 10 years after surgery. The main outcome measures were refractive predictability and stability, mean corneal keratometry, topographical cylinder, safety, efficacy, stability of visual acuity, and postoperative complications.
At 10 years, 156 (58%) of 267 eyes were within +/- 1.00 D and 209 (78%) were within +/- 2.00 D. One hundred and twenty-four eyes (46.4%) underwent retreatments because of overcorrection, regression, or both. The mean SE decreased (myopic regression) in eyes that did not undergo retreatment, with a mean magnitude of -1.33 +/- 2.0 D over 10 years (-1.13 +/- 0.20 D per year). One hundred and twenty-one (48.3%) of 267 eyes demonstrated increase in best spectacle-corrected visual acuity, and only eight eyes lost lines of vision because of cataract and posterior segment-related complications. The mean corneal haze score decreased gradually from 0.48 +/- 0.69 at three months to 0.09 +/- 0.33 at 10 years.
PRK for myopia of more than -6 D is a safe and effective procedure in the long-term.
评估准分子激光近视性屈光性角膜切削术（PRK）治疗近视度数高于-6屈光度（D）的长期疗效。
一项长期（10年）随访的回顾性、干预性病例系列研究。
本研究纳入了西班牙阿利坎特市阿利坎特眼科研究所191例等效球镜（SE）大于-6 D的近视患者的267只眼，使用VISX 20/20准分子激光（美国加利福尼亚州圣克拉拉）进行近视PRK治疗。所有患者在术后3个月、1年、2年、5年和10年进行评估。主要观察指标包括屈光预测性和稳定性、平均角膜曲率、地形图圆柱度、安全性、有效性、视力稳定性及术后并发症。
10年后，267只眼中有156只（58%）在±1.00 D范围内，209只（78%）在±2.00 D范围内。124只眼（46.4%）因过矫、回退或两者兼而有之接受了再次治疗。未接受再次治疗的眼平均SE下降（近视回退），10年期间平均下降幅度为-1.33±2.0 D（每年-1.13±0.20 D）。267只眼中有121只（48.3%）最佳矫正视力提高，仅有8只眼因白内障和后段相关并发症而视力下降。平均角膜 haze 评分从术后3个月的0.48±0.69逐渐降至10年时的0.09±0.33。
PRK治疗近视度数高于-6 D的长期疗效是安全有效的。
