Bokonjić D, Rosić N
Military Technical Institute and Military Medical Academy, Belgrade.
Arh Hig Rada Toksikol. 1991 Dec;42(4):359-65.
The aim of this study was to compare the anticonvulsive and protective effects of diazepam and midazolam in rats poisoned by chemical warfare agents. In rats treated with soman, sarin or VX, the anticonvulsive effects of midazolam and diazepam were of similar magnitude. Atropine and oxime HI-6 decreased the toxicity of soman, sarin and VX 1.65, 2.06 and 18.3 times, respectively. The introduction of diazepam and midazolam in the therapy of rats poisoned by VX and sarin led to further improvement of protective indices. Midazolam was even more effective than diazepam. A reliable protective effect was obtained with the lowest dose of both benzodiazepines used (0.5 mg/kg). The specific benzodiazepine antagonist flumazenil abolished, almost completely, the protective effect of both benzodiazepines. These data confirmed a significant role of the gabaergic system in poisoning with organophosphorus compounds, especially during the initial stage of intoxication.
本研究的目的是比较地西泮和咪达唑仑对化学战剂中毒大鼠的抗惊厥和保护作用。在用梭曼、沙林或VX处理的大鼠中，咪达唑仑和地西泮的抗惊厥作用程度相似。阿托品和肟HI-6分别将梭曼、沙林和VX的毒性降低了1.65倍、2.06倍和18.3倍。在VX和沙林中毒大鼠的治疗中引入地西泮和咪达唑仑可进一步提高保护指数。咪达唑仑比地西泮更有效。使用两种苯二氮䓬类药物的最低剂量（0.5mg/kg）均获得了可靠的保护作用。特异性苯二氮䓬类拮抗剂氟马西尼几乎完全消除了两种苯二氮䓬类药物的保护作用。这些数据证实了γ-氨基丁酸能系统在有机磷化合物中毒中，尤其是在中毒初期的重要作用。
