叶酸代谢途径基因多态性与儿童白血病幸存者的注意力障碍有关。
Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors.
作者信息
Krull Kevin R, Brouwers Pim, Jain Neelam, Zhang Linna, Bomgaars Lisa, Dreyer ZoAnn, Mahoney Donald, Bottomley Sarah, Okcu M Fatih
机构信息
Learning Support Center for Child Psychology, Texas Children's Hospital, Houston, TX, USA.
出版信息
J Pediatr. 2008 Jan;152(1):101-5. doi: 10.1016/j.jpeds.2007.05.047. Epub 2007 Oct 24.
OBJECTIVE
To test the hypothesis that 5,10-methylenetetrahydroreductase (MTHFR) polymorphisms can partially explain the individual variation in developing attention-deficit/hyperactivity disorder (ADHD) after acute lymphoblastic leukemia (ALL) therapy.
STUDY DESIGN
Parents of 48 survivors of childhood ALL completed a clinical diagnostic process to identify subtypes of ADHD. Genotyping was performed with peripheral blood DNA for MTHFR (C677T and A1298C) polymorphisms.
RESULTS
Eleven of the 48 patients (22.9%) had scores consistent with the inattentive symptoms of ADHD. Patients with genotypes related to lower folate levels (11 out of 39; 39.2%) were more likely to have ADHD. The A1298C genotype appeared to be the predominant linkage to the inattentive symptoms, leading to a 7.4-fold increase in diagnosis, compared with a 1.3-fold increase for the C677T genotype. Age at diagnosis and sex were not associated with inattentiveness.
CONCLUSIONS
Preliminary data imply a strong relationship between MTHFR polymorphisms and the inattentive symptoms of ADHD in survivors of childhood ALL.
目的
检验以下假设，即5,10-亚甲基四氢叶酸还原酶（MTHFR）基因多态性可部分解释急性淋巴细胞白血病（ALL）治疗后注意力缺陷多动障碍（ADHD）发生的个体差异。
研究设计
48名儿童ALL幸存者的父母完成了临床诊断流程以确定ADHD的亚型。采用外周血DNA对MTHFR（C677T和A1298C）基因多态性进行基因分型。
结果
48例患者中有11例（22.9%）的得分与ADHD的注意力不集中症状相符。叶酸水平较低相关基因型的患者（39例中的11例；39.2%）更易患ADHD。A1298C基因型似乎是注意力不集中症状的主要关联因素，与C677T基因型相比，其诊断增加了7.4倍，而C677T基因型仅增加了1.3倍。诊断时的年龄和性别与注意力不集中无关。
结论
初步数据表明MTHFR基因多态性与儿童ALL幸存者ADHD的注意力不集中症状之间存在密切关系。
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