Krull Kevin R, Brouwers Pim, Jain Neelam, Zhang Linna, Bomgaars Lisa, Dreyer ZoAnn, Mahoney Donald, Bottomley Sarah, Okcu M Fatih
Learning Support Center for Child Psychology, Texas Children's Hospital, Houston, TX, USA.
J Pediatr. 2008 Jan;152(1):101-5. doi: 10.1016/j.jpeds.2007.05.047. Epub 2007 Oct 24.
To test the hypothesis that 5,10-methylenetetrahydroreductase (MTHFR) polymorphisms can partially explain the individual variation in developing attention-deficit/hyperactivity disorder (ADHD) after acute lymphoblastic leukemia (ALL) therapy.
Parents of 48 survivors of childhood ALL completed a clinical diagnostic process to identify subtypes of ADHD. Genotyping was performed with peripheral blood DNA for MTHFR (C677T and A1298C) polymorphisms.
Eleven of the 48 patients (22.9%) had scores consistent with the inattentive symptoms of ADHD. Patients with genotypes related to lower folate levels (11 out of 39; 39.2%) were more likely to have ADHD. The A1298C genotype appeared to be the predominant linkage to the inattentive symptoms, leading to a 7.4-fold increase in diagnosis, compared with a 1.3-fold increase for the C677T genotype. Age at diagnosis and sex were not associated with inattentiveness.
Preliminary data imply a strong relationship between MTHFR polymorphisms and the inattentive symptoms of ADHD in survivors of childhood ALL.
检验以下假设，即5,10-亚甲基四氢叶酸还原酶（MTHFR）基因多态性可部分解释急性淋巴细胞白血病（ALL）治疗后注意力缺陷多动障碍（ADHD）发生的个体差异。
48名儿童ALL幸存者的父母完成了临床诊断流程以确定ADHD的亚型。采用外周血DNA对MTHFR（C677T和A1298C）基因多态性进行基因分型。
48例患者中有11例（22.9%）的得分与ADHD的注意力不集中症状相符。叶酸水平较低相关基因型的患者（39例中的11例；39.2%）更易患ADHD。A1298C基因型似乎是注意力不集中症状的主要关联因素，与C677T基因型相比，其诊断增加了7.4倍，而C677T基因型仅增加了1.3倍。诊断时的年龄和性别与注意力不集中无关。
初步数据表明MTHFR基因多态性与儿童ALL幸存者ADHD的注意力不集中症状之间存在密切关系。
