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亚甲基四氢叶酸还原酶（677C>T 和 1298A>C）多态性与精神障碍的关联：一项荟萃分析。

Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis.

机构信息

School of Basic Medicine, Shenyang Medical College, Shenyang, P.R. China.

Department of Forensic Medicine, China Criminal Police College, Shenyang, P.R. China.

出版信息

PLoS One. 2022 Jul 14;17(7):e0271170. doi: 10.1371/journal.pone.0271170. eCollection 2022.

DOI:10.1371/journal.pone.0271170
PMID:35834596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9282595/
Abstract

Recent studies showed that genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) is related to attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BD) and schizophrenia (SCZ). However, no consistent conclusion has been determined. This meta-analysis aims to interrogate the relationship between MTHFR gene polymorphisms (677C>T and 1298A>C) and the occurrence of ADHD, BD and SCZ. We retrieved case-control studies that met the inclusion criteria from the PubMed database. Associations between MTHFR polymorphisms (677C>T and 1298A>C) and ADHD, BD and SCZ were measured by means of odds ratios (ORs) using a random effects model and 95% confidence intervals (CIs). Additionally, sensitivity analysis and publication bias were performed. After inclusion criteria were met, a total of five studies with ADHD including 434 cases and 670 controls, 18 studies with BD including 4167 cases and 5901 controls and 44 studies with SCZ including 16,098 cases and 19913 controls were finally included in our meta-analysis. Overall, our meta-analytical results provided evidence that the MTHFR 677C>T was associated with occurrence of BD and SCZ, while the 1298A>C polymorphism was related to ADHD and BD, and additionally the sensitivity analysis indicated these results were stable and reliable. This may provide useful information for relevant studies on the etiology of psychiatric disorders.

摘要

最近的研究表明，5,10-亚甲基四氢叶酸还原酶（MTHFR）的遗传多态性与注意缺陷多动障碍（ADHD）、双相情感障碍（BD）和精神分裂症（SCZ）有关。然而，尚未得出一致的结论。本荟萃分析旨在探讨 MTHFR 基因多态性（677C>T 和 1298A>C）与 ADHD、BD 和 SCZ 发生之间的关系。我们从 PubMed 数据库中检索符合纳入标准的病例对照研究。使用随机效应模型和 95%置信区间（CI），通过比值比（OR）来衡量 MTHFR 多态性（677C>T 和 1298A>C）与 ADHD、BD 和 SCZ 之间的关联。此外，还进行了敏感性分析和发表偏倚分析。在符合纳入标准后，共有五项 ADHD 研究（包括 434 例病例和 670 例对照）、18 项 BD 研究（包括 4167 例病例和 5901 例对照）和 44 项 SCZ 研究（包括 16098 例病例和 19913 例对照）最终纳入本荟萃分析。总体而言，我们的荟萃分析结果提供了证据表明，MTHFR 677C>T 与 BD 和 SCZ 的发生有关，而 1298A>C 多态性与 ADHD 和 BD 有关，此外敏感性分析表明这些结果是稳定和可靠的。这可能为精神障碍病因学的相关研究提供有用的信息。

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