某些3-(1-金刚烷基)-4-取代-5-巯基-1,2,4-三唑的合成及其抗炎和镇痛活性
Synthesis and anti-inflammatory and analgesic activity of some 3-(1-adamantyl)-4-substituted-5-mercapto-1,2,4-triazoles.
作者信息
el-Emam A A, Ibrahim T M
机构信息
Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
出版信息
Arzneimittelforschung. 1991 Dec;41(12):1260-4.
PMID:1815527
Abstract
The synthesis of a series of 4,5-disubstituted-3-(1-adamantyl)- 1,2,4-triazoles is described. The compounds 3-(1-adamantyl)4-methyl, ethyl and benzyl-5-mercapto-1,2,4-triazoles (3a, 3b and 3f) produced a high dose-dependent anti-inflammatory activity against carrageenin-induced paw oedema in rats. The analgesic activity of these active compounds correlated with their anti-inflammatory activities.
摘要
本文描述了一系列4,5-二取代-3-(1-金刚烷基)-1,2,4-三唑的合成。化合物3-(1-金刚烷基)-4-甲基、乙基和苄基-5-巯基-1,2,4-三唑（3a、3b和3f）对角叉菜胶诱导的大鼠足爪水肿产生了高剂量依赖性抗炎活性。这些活性化合物的镇痛活性与其抗炎活性相关。
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