Goetzl Manlio A, Outman James E, Griebling Tomas L, Holzbeierlein Jeffrey M, Weigel John W, Thrasher J Brantley
Department of Urology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
J Am Coll Surg. 2008 Jan;206(1):144-7. doi: 10.1016/j.jamcollsurg.2007.06.295. Epub 2007 Sep 18.
This study was designed to evaluate the use and yield of fecal occult blood testing (FOBT) in an ambulatory urology clinic.
Patients seen in the ambulatory urology clinic were prospectively evaluated with FOBT. The test was performed only on patients when a rectal examination was indicated as part of their urologic evaluation. Patients who were found to have a positive FOBT were then referred for additional gastrointestinal evaluation.
One hundred eight patients were evaluated, including 57 men and 51 women. Eight patients (7%), including six men and two women, were found to be positive for fecal occult blood. Two patients were found to have upper gastrointestinal sources of bleeding (one gastritis with Barrett's esophagitis and one with a duodenal ulcer). Two patients had benign lower gastrointestinal sources of bleeding, including one with hyperplastic polyps and one with a tubular adenoma. One patient was diagnosed with a moderately differentiated adenocarcinoma of the sigmoid colon. One had negative followup fecal occult blood test, and two were lost to followup.
Addition of FOBT to routine digital rectal examination performed in the ambulatory urology clinic is an inexpensive and simple test that can detect otherwise asymptomatic underlying gastrointestinal pathology. Although the six-sample test is a preferred test for colorectal cancer screening, a digital FOBT during routine urologic evaluation can detect a clinically significant upper or lower gastrointestinal lesion, at the same time increase compliance with FOBT. Larger, prospective studies are needed to confirm the benefit of digital FOBT during a routine urologic visit.
本研究旨在评估粪便潜血试验(FOBT)在门诊泌尿外科诊所的应用及检出率。
对门诊泌尿外科诊所的患者进行前瞻性粪便潜血试验评估。该检查仅在直肠指检作为泌尿外科评估的一部分时对患者进行。粪便潜血试验呈阳性的患者随后被转诊进行进一步的胃肠道评估。
共评估了108例患者,其中男性57例,女性51例。8例患者(7%)粪便潜血呈阳性,包括6名男性和2名女性。2例患者有上消化道出血来源(1例为伴有巴雷特食管炎的胃炎,1例为十二指肠溃疡)。2例患者有良性下消化道出血来源,包括1例增生性息肉和1例管状腺瘤。1例患者被诊断为乙状结肠中分化腺癌。1例患者粪便潜血试验随访结果为阴性,2例失访。
在门诊泌尿外科诊所的常规直肠指检中增加粪便潜血试验是一种廉价且简单的检查,可检测出无症状的潜在胃肠道病变。虽然六样本检测是结直肠癌筛查的首选检测方法,但在常规泌尿外科评估中进行数字粪便潜血试验可检测出临床上有意义的上消化道或下消化道病变,同时提高粪便潜血试验的依从性。需要更大规模前瞻性研究来证实常规泌尿外科就诊时数字粪便潜血试验的益处。