Singh Uma Sharan, Shankar Ravi, Yadav Gaya P, Kharkwal Geetika, Dwivedi Anila, Keshri Govind, Singh M M, Moulik P R, Hajela K
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India.
Eur J Med Chem. 2008 Oct;43(10):2149-58. doi: 10.1016/j.ejmech.2007.10.035. Epub 2007 Nov 17.
Several regioisomeric tetrazolyl indole derivatives with structurally modified alkyl substituents at the tetracyclic indole nitrogen containing N-ethyl amino tetrazole moiety have been synthesized and screened for their ER binding affinity, agonist (estrogenic), antagonist (antiestrogenic) and anti-implantation activities. N-2 regioisomers were found to be moderately antagonists and one compound showed 100% contraceptive efficacy at 10 mg/kg dose. Molecular docking studies carried out in comparison to estradiol and raloxifene showed different binding modes of the two regioisomers to the binding site.
