多发性骨髓瘤：一种具有全身表现的原发性骨肿瘤。

Multiple myeloma: primary bone tumor with systemic manifestations.

作者信息

Bilsky Mark H, Azeem Syed

机构信息

Department of Neurosurgery, Box 71, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

出版信息

Neurosurg Clin N Am. 2008 Jan;19(1):31-40. doi: 10.1016/j.nec.2007.09.001.

DOI:10.1016/j.nec.2007.09.001

PMID:18156045

Abstract

Multiple myeloma is a plasma cell dyscrasia that frequently involves the bone marrow of the spine. These tumors are typically chemosensitive and radiation sensitive. Multiple myeloma promotes osteoclast activation and osteoblast inhibition, resulting in osteolysis of the vertebral bodies and subsequent compression fractures. Rarely is open surgery for decompression and instrumentation indicated. The presence of diffuse osteoporosis in patients with multiple myeloma increases the probability of failed fixation in this population.

摘要

多发性骨髓瘤是一种浆细胞发育异常疾病，常累及脊柱骨髓。这些肿瘤通常对化疗和放疗敏感。多发性骨髓瘤会促进破骨细胞活化并抑制成骨细胞，导致椎体骨质溶解及随后的压缩性骨折。很少需要进行开放手术减压和内固定。多发性骨髓瘤患者存在弥漫性骨质疏松会增加该人群内固定失败的可能性。