多发性骨髓瘤的并发症

Complications of multiple myeloma.

作者信息

Bladé Joan, Rosiñol Laura

机构信息

Institute of Hematology and Oncology, Postgraduate School of Hematology Farreras-Valentí, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, Spain.

出版信息

Hematol Oncol Clin North Am. 2007 Dec;21(6):1231-46, xi. doi: 10.1016/j.hoc.2007.08.006.

DOI:10.1016/j.hoc.2007.08.006

PMID:17996596

Abstract

Multiple myeloma, also known as myeloma or plasma cell myeloma, is a progressive hematologic disease. Complications of multiple myeloma include renal insufficiency, hematologic complications (anemia, bone marrow failure, bleeding disorders), infections, bone complications (pathologic fractures, spinal cord compression, hyercalcemia), and neurologic complications (spinal cord and nerve root compression, intracranial plasmacytomas, leptomeningeal involvement, among others). This article reviews these various complications connected to multiple myeloma, examining their various causes and possible treatment.

摘要

多发性骨髓瘤，也称为骨髓瘤或浆细胞骨髓瘤，是一种进行性血液系统疾病。多发性骨髓瘤的并发症包括肾功能不全、血液学并发症（贫血、骨髓衰竭、出血性疾病）、感染、骨骼并发症（病理性骨折、脊髓压迫、高钙血症）以及神经学并发症（脊髓和神经根压迫、颅内浆细胞瘤、软脑膜受累等）。本文综述了与多发性骨髓瘤相关的这些各种并发症，探讨了它们的各种病因及可能的治疗方法。