van Zelm Menno C, van der Burg Mirjam, van Dongen Jacques J M
Erasmus MC, University Medical Center, Department of Immunology, Rotterdam, The Netherlands.
Cell Cycle. 2007 Dec 1;6(23):2890-5. doi: 10.4161/cc.6.23.4952.
B lymphocytes contribute to the immune system by the production of antigen-specific antibodies. When naive mature B-lymphocytes recognize antigen with their specific Ig receptors, they will undergo clonal proliferation and differentiation, thereby generating a large number of long-lived memory B cells and plasma cells that produce and secrete antigen-specific antibodies. Recently, we generated new insights on the peripheral B-cell compartment in mice and man, supported by the introduction of a novel molecular assay that quantifies the replication history of B lymphocytes. Our data indicate that naive mature B lymphocytes are able to undergo antigen-independent homeostatic proliferation. Furthermore, the extent of proliferation differs substantially between T-cell dependent and T-cell independent B-cell responses. Thus, three unique proliferation stages occur in the peripheral B-cell compartment. Now that we have identified the B-cell subsets that undergo proliferation, it is a challenge to investigate the initiation and regulation of the proliferation processes. To support the understanding of each of the three proliferation stages, we present our view on the impact of the different proliferation stages on B-cell maturation, the potential molecular mechanisms underlying these processes, and the potential implications in human immunological diseases.
B淋巴细胞通过产生抗原特异性抗体对免疫系统做出贡献。当未成熟的成熟B淋巴细胞用其特异性Ig受体识别抗原时，它们将经历克隆增殖和分化，从而产生大量产生并分泌抗原特异性抗体的长寿记忆B细胞和浆细胞。最近，在一种量化B淋巴细胞复制历史的新型分子检测方法的支持下，我们对小鼠和人类外周B细胞区室有了新的认识。我们的数据表明，未成熟的成熟B淋巴细胞能够进行抗原非依赖性稳态增殖。此外，T细胞依赖性和T细胞非依赖性B细胞反应之间的增殖程度有很大差异。因此，在外周B细胞区室中会出现三个独特的增殖阶段。既然我们已经确定了发生增殖的B细胞亚群，那么研究增殖过程的起始和调控就是一项挑战。为了帮助理解这三个增殖阶段中的每一个，我们阐述了不同增殖阶段对B细胞成熟的影响、这些过程潜在的分子机制以及它们在人类免疫疾病中的潜在意义。
