Peyruchaud Olivier
INSERM U664, Faculté de Médecine Laennec, rue Guillaume Paradin, 69372 Lyon Cedex 08, France.
J Soc Biol. 2007;201(3):229-36. doi: 10.1051/jbio:2007033.
Bone is a common metastatic site for many cancers. Tumor cells located in the bone marrow cavity disturb the natural balance (bone remodelling) established between new bone formation performed by osteoblasts and bone resorption carried out by osteoclasts. Tumor cells produce many factors including growth factors and cytokines (PTHrP, ET-1, BMPs, others...) that stimulate either ostoclast activity leading to osteolytic lesions or osteoblast activity generating osteosclerotic bone metastases. Growth factors released from resorbed bone matrix or throughout osteoblastic bone formation sustain tumor growth. Therefore, bone metastases are the site of vicious cycles wherein tumor growth and bone metabolism sustain each other.
骨是许多癌症常见的转移部位。位于骨髓腔的肿瘤细胞会扰乱成骨细胞形成新骨与破骨细胞进行骨吸收之间建立的自然平衡（骨重塑）。肿瘤细胞会产生多种因子，包括生长因子和细胞因子（甲状旁腺激素相关蛋白、内皮素-1、骨形态发生蛋白等），这些因子要么刺激破骨细胞活性导致溶骨性病变，要么刺激成骨细胞活性产生骨硬化性骨转移。从吸收的骨基质中释放或在整个成骨细胞骨形成过程中释放的生长因子会维持肿瘤生长。因此，骨转移是一个恶性循环的部位，肿瘤生长和骨代谢相互维持。
