Viso Ana Teresa Rodriguez, de Castro Barbosa Thaís, Yamamoto Lídia, Pagliari Carla, Fernandes Elaine Raniero, Brasil Roosecelis Araújo, Andrade Heitor Franco de, Duarte Maria Irma Seixas, Barone Antônio Alci
Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP.
Rev Inst Med Trop Sao Paulo. 2007 Nov-Dec;49(6):371-8. doi: 10.1590/s0036-46652007000600007.
The pathogenesis of chronic hepatitis C is still a matter of debate. CD4+ and CD8+ T lymphocytes (TL) are typically observed within the portal and periportal spaces of affected livers, but their functional role in hepatitis C progression has not been fully elucidated.
CD4+ and CD8+ TL were quantified by immunohistochemistry in portal and periportal spaces of 39 liver biopsies from patients with chronic hepatitis C. They were associated to demographic data, histological parameters, laboratory findings of patients and hepatitis C genotypes.
There was high numbers of CD4+ and CD8+ TL from which the density of CD4+ T was higher than CD8+ TL in portal and periportal spaces. CD4+ and CD8+ TL were directly correlated to intensity of interface hepatitis. CD8+ TL correlated to serum enzyme levels.
The high numbers of CD4+ and CD8+ TL in portal and periportal spaces and their correlation to interface hepatitis suggest that hepatitis C evolution depends on the action of intrahepatic T lymphocytes, lending support to the notion of an immune-mediated mechanism in the pathogenesis of chronic hepatitis C.
丙型肝炎的发病机制仍存在争议。在受影响肝脏的门静脉和门周间隙中通常可观察到CD4+和CD8+ T淋巴细胞（TL），但其在丙型肝炎进展中的功能作用尚未完全阐明。
通过免疫组织化学对39例慢性丙型肝炎患者肝活检的门静脉和门周间隙中的CD4+和CD8+ TL进行定量。将其与患者的人口统计学数据、组织学参数、实验室检查结果以及丙型肝炎基因型相关联。
门静脉和门周间隙中有大量的CD4+和CD8+ TL，其中CD4+ T的密度高于CD8+ TL。CD4+和CD8+ TL与界面性肝炎的强度直接相关。CD8+ TL与血清酶水平相关。
门静脉和门周间隙中大量的CD4+和CD8+ TL及其与界面性肝炎的相关性表明，丙型肝炎的进展取决于肝内T淋巴细胞的作用，这支持了慢性丙型肝炎发病机制中免疫介导机制的观点。
