Department of Nutrition & Institute of BioMedical Nutrition, Hungkuang University, Taichung, Taiwan.
Clin Biochem. 2013 Jun;46(9):745-9. doi: 10.1016/j.clinbiochem.2013.03.016. Epub 2013 Apr 2.
BACKGROUND/AIMS: The incidence of metabolic syndrome (MS) in hepatitis C patients in Taiwan is not well known. Although the ratio of CD4(+)/CD8(+) T lymphocytes is considered to possibly affect the pathogenesis of hepatitis C, the effects of MS on CD4(+)/CD8(+) T lymphocytes remain unknown. The aims of this study to assess (1) the incidence of MS, (2) the inflammation status and fatty changes of liver, and (3) changes in their CD4(+)/CD8(+) T-lymphocyte ratio in patients with hepatitis C.
60 hepatitis C patients were classified into MS or non-MS group. The terms of anthropometric data, MS components, and T-lymphocytes were assessed.
The proportion of hepatitis C patients suffering from MS was 26.7% in this study. The CD4(+)/CD8(+) T-lymphocyte ratios were higher in patients with MS than non-MS group. Hepatitis C patients with MS also had higher levels of ferritin than non-MS. Moreover, the level of ferritin positively correlated with the severity of fatty liver. The CD4(+)/CD8(+) T-lymphocyte ratio is also positively correlated with ferritin level and the severity of fatty liver.
Hepatitis C patients with MS had higher ratio of CD4(+)/CD8(+) T lymphocyte, which is associated with a high inflammatory response and a fatty change of liver.
背景/目的：台湾地区丙型肝炎患者代谢综合征（MS）的发病率尚不清楚。虽然 CD4(+)/CD8(+)T 淋巴细胞比值可能影响丙型肝炎的发病机制，但 MS 对 CD4(+)/CD8(+)T 淋巴细胞的影响尚不清楚。本研究旨在评估（1）MS 的发病率，（2）肝脏的炎症状态和脂肪变化，以及（3）丙型肝炎患者 CD4(+)/CD8(+)T 淋巴细胞比值的变化。
将 60 例丙型肝炎患者分为 MS 或非 MS 组。评估了人体测量数据、MS 成分和 T 淋巴细胞的术语。
本研究中，MS 患者的丙型肝炎患者比例为 26.7%。MS 组患者的 CD4(+)/CD8(+)T 淋巴细胞比值高于非 MS 组。MS 丙型肝炎患者的铁蛋白水平也高于非 MS 组。此外，铁蛋白水平与脂肪肝的严重程度呈正相关。CD4(+)/CD8(+)T 淋巴细胞比值也与铁蛋白水平和脂肪肝的严重程度呈正相关。
MS 的丙型肝炎患者 CD4(+)/CD8(+)T 淋巴细胞比值较高，与炎症反应强烈和肝脏脂肪变性有关。
