Diaz Roberto Jose, Laughlin Suzanne, Nicolin Gary, Buncic J Raymond, Bouffet Eric, Bartels Ute
Division of Neurosurgery, Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, 1403-29th St. N.W., Calgary, AB, Canada T2N 2T9.
Childs Nerv Syst. 2008 Jun;24(6):707-12. doi: 10.1007/s00381-007-0565-5. Epub 2007 Dec 22.
Some children with optic pathway gliomas present with proptosis related to intraorbital tumor extension. The radiological assessment of chemotherapeutic response in these patients can be complicated by irregular tumor shape and lack of relation between tumor volume and cosmetic effect.
We propose that proptosis measurements and derivation of a proptosis index can be a useful adjunct to the measurement of tumor volume in the radiological assessment of chemotherapeutic response. The proptosis index was derived as the ratio of the difference in proptosis between eyes postchemotherapy to that prechemotherapy. A series of six patients with proptosis and the diagnosis of an optic nerve tumor from an optic pathway glioma registry demonstrate by case example the correlation between the proptosis index and the clinical and radiographic response to chemotherapy.
We have found that a proptosis index <1 correlates with a chemotherapeutic maintained response and an index >1 correlates with progressive disease.
一些患有视神经通路胶质瘤的儿童会出现与眶内肿瘤扩展相关的眼球突出。这些患者化疗反应的放射学评估可能会因肿瘤形状不规则以及肿瘤体积与美容效果缺乏关联而变得复杂。
我们提出，在化疗反应的放射学评估中，眼球突出测量和眼球突出指数的推导可作为肿瘤体积测量的有用辅助手段。眼球突出指数是化疗后双眼眼球突出差异与化疗前双眼眼球突出差异的比值。来自视神经通路胶质瘤登记处的一系列6例有眼球突出且诊断为视神经肿瘤的患者通过实例展示了眼球突出指数与化疗的临床及影像学反应之间的相关性。
我们发现，眼球突出指数<1与化疗维持反应相关，而指数>1与疾病进展相关。
