Aupperle Robin L, Denney Douglas R, Lynch Sharon G, Carlson Susan E, Sullivan Debra K
Department of Psychology, University of Kansas, 1415 Jayhawk Blvd, Lawrence, KS 66045-7556, USA.
J Behav Med. 2008 Apr;31(2):127-35. doi: 10.1007/s10865-007-9139-y.
Depression is a common problem among patients with multiple sclerosis (MS). Previous research has shown differences between MS patients and controls in the levels of certain fatty acids, and differences in many of these same fatty acids have also been reported in psychiatric patients with major depression. The current study sought to determine whether fatty acid levels in MS patients might be associated with depression. Fatty acids were measured in red blood cells (RBCs) for 38 patients with relapsing-remitting MS and 33 healthy controls who also completed 3-day dietary records and depression questionnaires. Levels of certain omega-3 and omega-6 fatty acids were lower and levels of certain monounsaturated and saturated fatty acids were higher in the MS patients. These differences were generally of medium effect size and occurred despite the fact that no differences were found between the two groups in dietary intake of any fatty acids. However, neither RBC nor dietary fatty acid levels were related to depression in the MS sample.
抑郁症是多发性硬化症（MS）患者中的常见问题。先前的研究表明，MS患者与对照组在某些脂肪酸水平上存在差异，并且在重度抑郁症的精神病患者中也报告了许多这些相同脂肪酸的差异。当前的研究旨在确定MS患者的脂肪酸水平是否可能与抑郁症有关。对38例复发缓解型MS患者和33例健康对照者的红细胞（RBC）中的脂肪酸进行了测量，这些对照者还完成了3天的饮食记录和抑郁症问卷调查。MS患者中某些ω-3和ω-6脂肪酸水平较低，某些单不饱和脂肪酸和饱和脂肪酸水平较高。这些差异通常具有中等效应大小，尽管两组在任何脂肪酸的饮食摄入量上均未发现差异，但差异仍然存在。然而，在MS样本中，红细胞脂肪酸水平和饮食脂肪酸水平均与抑郁症无关。
